Abstract: OBJECTIVE To investigate the clinical practice of pharmacists on granulocytopenia induced by rifampicin. METHODS Combined with the clinical data of granulocytopenia induced by rifampicin, clinical pharmacists used the theoretical knowledge of clinical pharmacology to manage drug treatment by participating in the identification of adverse drug reactions and the selection of antibiotics. RESULTS The patients with granulocytopenia induced by rifampicin, should be given prompt treatment, such as Likoxine and so on. CONCLUSION In the clinical work, clinical pharmacists shall give full play to their professional advantages, paying attention to the adverse reactions caused by drugs, and early identifying adverse reactions, to provide a reasonable treatment plan for clinicians to reflect their value.