Abstract: OBJECTIVE To standardize the clinical use of vinpocetine injection, one of the adjuvant drugs in Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine. The PDCA cycle prescription evaluation be used in this process. METHODS The PDCA cycle method was implemented, the clinical department of using vinpocetine injection in the hospital as the research object. The pharmacy department established the special evaluation team for the use of vinpocetine injection and formulate evaluation rules. The patients who used vinpocetin injection in the hospital were selected for review in three consecutive phases. After feedback, communication, consensus, publicity and so on, the differences in the rational use of vinpocetine injection between the three phases were compared to evaluate the effect of special reviews. RESULTS After continuous interventions, the irrational rate of the use of vinpocetine injection in the whole hospital decreased from 39.80% to 13.30%(P<0.05). The rationality has been greatly improved, especially in the department with higher irrational rate in the first phase. CONCLUSION PDCA cycle significantly improve the rationality of the use of vinpocetine injection. It can be promoted in other drug usage management.