Abstract: OBJECTIVE To study on efficiency of domestic linazolamide in the treatment process of severe pneumonia infected with gram-positive cocci and its influencing factors. METHODS The 80 patients with severe pneumonia infected with gram-positive cocci were treated in Anyang People's Hospital from January 2016 to December 2017. They were considered as study objects and were analyzed prospectively. They were divided into observation group treated with domestic linzolamide (n=42) and control group treated with norvancomycin(n=38). The treatment effects were observed and compared. At the same time, according to the recurrence or not for these patients, they were divided into efficiency group(n=49) and non-efficiency group(n=31). The risk of prognostic factors were analyzed by logistic regression model. RESULTS After treatment, the index including MDA, IL-1β and TNF-α were significantly lower in observation group compared with the control group(P<0.05), while the level of SOD, LHP, TGF-b, blood gas analysis index and lung function index in observation group was higher than that of control group(P<0.05). The effective rate in the observation group was significantly higher than the control group(73.81% vs 47.37%, P<0.05). The results of logistic regression analysis showed that APACHEⅡ, whether the total volume of cumulative fluid in 72 h was in a positive balance, and the ventilation pattern were independent risk factors for the prognosis of the patients. CONCLUSION Domestic linazolamide is used in the treatment process of severe pneumonia infected with gram-positive cocci, and it can effectively improve the pulmonary function of the patients and reduce the inflammatory reaction of the body. The therapeutic effect is remarkable. In addition, preventive measures shall be taken in time to improve the prognosis of patients with need for mechanica1ventilation and positive balance of fluid accumulationin 72 h.