Abstract: OBJECTIVE To evaluate the effectiveness and safety of cefazolin sodium for azole combined with Yanhuning injection in treatment of the acute infective valve endocarditis, in order to provide basis for evidence-based in the rationality of the combination. METHODS Retrieved from CNKI, Wanfang database, Weipu database, CBM searching RCTs from January 1990 to February 2018. The two evaluators choose trials and evaluated quality, valid data were entered meta-analysis by Rev Man 5.3 software. RESULTS Eleven RCTs were included in effectiveness. From the results of meta-analysis, the effectiveness of test group (cefazolin sodium for azole combined with Yanhuning injection) was superior to the control group(single use of cephalosporins for azole sodium) with statistical significanceOR=4.07, 95%CI(2.66, 6.25), Z=6.43, P<0.000 01. Seven RCTs were included outcome indicators of adverse reactions. From the results of meta-analysis, test group was same to the control group in the incidence of adverse drug reaction without statistical significanceOR=0.60, 95%CI(0.29, 1.28), Z=1.32, P=0.19. CONCLUSION The effectiveness of cefazolin sodium for azolein combined with Yanhuning injection in treatment of the acute infective valve endocarditis is superior than the single use of cephalosporins for azole sodium, but there is no difference between the two groups in the incidence of adverse drug reaction.