Abstract: OBJECTIVE To observe the effect of formula granule of Fangji Fuling Decoction on the clinical expressions and advanced glycation end products(AGEs) in patients with post-thrombotic syndrome(PTS). METHODS Sixty patients with PTS were randomly divided into experimental group and control group according to 1:1 random number word, 30 cases in each group. Both groups of patients were given conventional treatment, not balloon expansion such interventional surgical of treatment, only oral aspirin such anticoagulants and wearing medical elastic stockings. On the basis of this, the experimental group was given oral Fangji Fuling Decoction prescription granules one dose per day, twice a day at noon and evening; the control group was given 12 g of oral choroid shutong bolus, three times a day. The score of disease status and the level of AGEs in venous blood were compared between the 2 groups before and after treatment. RESULTS The disease grading decision standard scores of the experimental group were lower than before treatment and concurrent control group, the difference was statistically significant(P<0.05).There was no significant difference in the scores of disease grading decision standard before and after treatment in the control group(P>0.05). The Villalta scores and serum AGEs levels in the experimental group were better than before treatment and concurrent control group, the difference was statistically significant(P<0.05). There was no statistical difference in serum AGEs before and after treatment in the control group(P>0.05). There were 2 cases of vomiting in the experimental group, the incidence rate was 6.67%, and 3 cases in the control group occurred abdominal distension, the incidence was 13.33%. CONCLUSION Fangji Fuling Decoction prescription granules can improve the clinical manifestation of PTS patients, reduce the formation of AGEs and delay the occurrence of PTS.