Abstract: OBJECTIVE To provide a reference for the industrial production of the extraction process of Compound Biqing granules by exploring the optional extraction process parameters based on determing the index weight. METHODS With the extraction capacity of diosgenin, colchicine, quercetin and ratio of extraction as comprehensive evaluation indexes, the weighting coefficient in four synthetic evaluation indexes was determined by analytic hierarchy process(AHP), criteria importance through intercriteria correlation(CRITIC) method, and mixed weighted AHP-CRITIC. And ethanol-extracting process was optimized by orthogonal test. RESULTS Mixed weighted AHP-CRITIC was more scientific, reasonable, and stable than AHP and CRITIC. The optimal process parameters were confirmed to be decocting for twice with 1.0 h in each by eight times the amount of 70% ethanol, according to the weight coefficient determined by comprehensive evaluation. CONCLUSION The weight coefficient determined by mixed weighted AHP-CRITIC is objective, real and can reflect the compound compatibility information. The optimized technology is stable, feasible, and suitable for standardized production of Compound Biqing granules.