Abstract: OBJECTIVE To elucidate multicomponent-multi-target-multi-channel analysis by network pharmacology, so as to provide a theoretical reference for further study of the mechanism of antihypertensive action of Ji Mai Tong tablet. METHODS By the TCMSP database, combined with oral bioavailability (≥ 30%) analysis and resistance (≥ 0.18), screening of active ingredients in Ji Mai Tong tablet. Target prediction analysis was carried out by Drugbank and TCMSP database, and the related genes of hypertension disease were screened through GENCARD database. DAVID and KEGG database were combined to carry out GO analysis and path analysis, and Cystoscope software was used to construct the network of compound-target-path. RESULTS The 33 compounds were obtained and 148 number of related potential target genes, which could map to 223 signalling pathways. Among these pathways, 31 pathways were closely related to the development of hypertension. AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, TNF signaling pathway, Adrenergic signaling in cardiomyocytes and Focal adhesion were the hinge of the whole hypotensive mechanism of Ji Mai Tong tablet. CONCLUSION It is indicated that Ji Mai Tong tablets could regulate vascular endothelial function, inflammatory reaction, calcium and sodium transport, glucose and lipid metabolism and other involved in vasodilation, and then improve inflammation, regulate the body's metabolism, medulating the transport of ions and so on, resulting in antihypertensive effect.