Abstract: OBJECTIVE To prepare Chrysanthemi Indici Flos standard decoction and to study the quality standard. METHODS Fifteen batches of Chrysanthemi Indici Flos standard decoction were prepared according to the standardization method. With buddleoside as the quantitative detection index, the transfer rate and extraction rate were calculated and the UPLC characteristic chromatogram analysis method was established. RESULTS According to the measurement of 15 batches of Chrysanthemi Indici Flos standard decoction, the transfer rate ranged from 29.6% to 38.2% and extraction rate was at the range of 23.1%~31.4%. The Similarity Evaluation Chromatographic Fingerprint of traditional Chinese medicine TCM was used to analyze and compare the characteristic chromatograms, 12 common peaks were determined and 9 of them were identified. Moreover, the similarities were all over 0.90. CONCLUSION Samples were prepared by a standard method. The determination method displayed good precision, stability and repeatability. Therefore, this study can provide a reference for the quality control of Chrysanthemi Indici Flos formula granules.