Abstract: OBJECTIVE To investigate the performance of different polymers in the preparation of Nimodipine amorphous solid dispersion prepared by hot melt extrusion. METHODS Copovidone and hydroxypropyl methylcellulose acetate succinate (L, M and H grade) were selected as the carrier polymers to prepare nimodipine solid dispersions by hot melt extrusion. Polarized light microscopy, differential scanning calorimetry and powder diffraction were used to test the physiochemical properties, in-situ optical fiber was used to test the dynamics solubility of prepared solid dispersions, the stability test was also studied. RESULTS Copovidone was easier to extruded, the torque value of screw was <30% and the die pressure was <15 bar; the prepared solid dispersion was easier to be crushed, supersaturation reached 6 000 μg·mL^-1 and dissolved quickly, and had good stability in 2 months stress test. CONCLUSION Copovidone is more appropriate for the preparation of nimodipine solid dispersion by hot melt extrusion.