Abstract: OBJECTIVE To analyze and discuss the stability of different administration ways of omeprazole sodium for injection with transfusion fluid. METHODS Simulated 2 administration ways of omeprazole sodium for intravenous infusion and intravenous injection. The pH value at different periods was determined with pH meter, the differences of full absorbance value using 2 administration ways were measured by UV. Then the contents and the changes of omeprazole sodium were calculated. RESULTS The formulation for injection could only be used for intravenous injection and should be used as fast as possible after diluting as it decreased significantly after 3 h. And the other formulation remained stable within 6 h and could be used for intravenous infusion. CONCLUSION Due to different administration ways of omeprazole, the stability of 2 formulations vary obviously. So it shall follow the instructions of administration ways of these 2 drugs of omeprazole sodium.