Abstract: With the rapid development of high-throughput sequencing technology and gene chips, non-coding RNAs (ncRNA) account for a high proportion of the mammalian genome. Studies shown that long ncRNA (lncRNA) and micro RNA (miRNA) are the two major subgroups of ncRNA. A number of studies have showed crucial functions for lncRNAs in cancer in the past few years. LncRNA NEAT1 is a class of lncRNA that play important roles in the structural formation and structural maintenance of paranuclear paraspeckles. LncRNA NEAT1 was reported to be associated with cancer progression, cancer treatment and prognosis, in addition. NEAT1 is involved in cell survival and proliferation, cell cycle, apoptosis, invasion and migration, and cell differentiation in cancer. In this review, the function and mechanisms of lincRNA NEAT1 in cancer and its regulation for the genes expression are summarized.