Abstract: OBJECTIVE To evaluate the clinical efficacy of Esberitox and Leucogen treating pediatric infection which lead to neutropenia. METHODS A total of 80 children with neutropenia in pediatric inpatient department from January 2013 to March 2017 were analyzed retrospectively. According to the different kinds of medicine, patients were divided into four groups:control group, Esberitox group, Leucogen group and combination group, 20 cases in each group were given symptomatic treatment. Comparing of the proportion of increasing eukocyte and granulocyte of controlling infection, the rate of controlling infection, the days of hospitalization in the four guoups during giving treantment after 3-7 d. RESULTS The ratio of leukocyte to granulocyte in Leucogen group and combination group was significantly higher than that in the control group (P<0.05), and the days of hospitalization in Leucogen group and combination group were shorter than the control group (P<0.05). The rate of leukocyte and granulocyte in combination group was higher than the Esberitox group (P<0.05). The days of abatement of fever, the normal days of CRP, the days of cough had no difference in the four groups. CONCLUSION Leucogen group and combination group can improve leukocyte and granulocyte count back to normal, they shorter hospitalization days. There is no obvious adverse reaction between the two groups.