Abstract: OBJECTIVE To optimize preparation technology of matrix formulation of Huayusan gel patch. METHODS The orthogonal experiment was used to adjust the dosage of sodium polyacrylate, gelatin, glycerinum and propylene glycol and determine optimized proportion of different excipients in matrix with temperciance, permanent adhesion, peel strength, tracing ability of gel patch as the indexes. RESULTS The optimized proportion of matrix formulation in Huayusan gel patch was sodium polyacrylate:gelatin:glycerinum:propylene glycol=4:3:3:2. CONCLUSION The best composition of prescription of Huayusan gel patch is selected. The gel patch made by this prescription is glossy smooth, with pretty good adhesive and humectant properties.