Abstract: OBJECTIVE To compare the pharmacodynamics between 2% and 1% propofol and reduce the related adverse reactions caused by excessive lipid input in propofol anesthesia. METHODS Eighty two patients undergoing elective laparoscopic myomectomy were randomly divided into 1% propofol group and 2% propofol group, with 41 cases in each group; Propofol was administrated with 4 μg·mL^-1 target plasma concentration during anesthesia induction and with adjusted target plasma concentration during operation according to the BIS value which was maintained at about 50 (45-55) in both group. The time of consciousness loss, propofol dosage at consciousness loss, wake-up time and total amount of propofol infusion were recorded. RESULTS The time of consciousness loss, propofol dosage at consciousness loss and total amount of propofol infusion in 2% propofol group were higher than that in 1% propofol group and the wake-up time of 2% propofol group was shorter than that in 1% propofol group (P<0.05). The infusion of lipid dosage in 2% propofol group was 59% of that in 1% propofol group. CONCLUSION The 2% propofol used in patients undergoing propofol target controlled infusion anesthesia can reduce the infusion of lipid dosage and the related adverse events caused by excessed lipid infusion. The actual pharmacodynamics of 2% propofol is approximately equal to 1.7 times of 1% propofol during anesthesia of patients with laparoscopic myomectomy.