Abstract: OBJECTIVE To investigate the effect of differnet dosages of hydroxyethyl starch 200/0.5 sodium chloride on coagulation function and hemodynamics in patients undergoing general anesthesia. METHODS One hundred and eighteen patients with general anesthesia who underwent surgical treatment in Deqing People's Hospital from October 2014 to October 2017 were enrolled and divided into small dose group (10 mL·kg^-1) and high dose group (20 mL·kg^-1) according to the dose of hydroxyethyl starch 200/0.5 sodium chloride(n=59). The coagulation function and hemodynamic changes were compared between the two groups. RESULTS There were no significant differences in coagulation function indexes (prothrombin time, activated partial thromboplastin time, blood platelet and fibrinogen) and hemodynamic indexes (heart rate, central venous pressure, mean artery pressure and systemic vascular resistance) between the two groups at different time points. CONCLUSION Infusion of 10, 20 mL·kg^-1 hydroxyethyl starch 200/0.5 sodium chloride before induction of general anesthesia can effectively maintain intraoperative hemodynamic stability effectively, and has little effect on coagulation function.