Abstract: OBJECTIVE To prepare Telmisartan and Amlodipine tablets by the methods of Telmisartan tablets coated with Amlodipine suspension and assess the dissolution and stability. METHODS Telmisartan blend was prepared by the one step granulation process using fluidized bed. The blend was compressed by rotary tablet press and then coated with amlodipine suspension. The formulations were optimized by orthogonal experiment design utilizing dissolution similarity f₂ as an evaluation index. The drug content and impurity were analyzed by HPLC. The stability study was conducted under both accelerated and long-term conditions. RESULTS The optimized formulation of Telmisartan and Amlodipine tablets showed acceptable quality and stability and similar dissolution profiles with the reference. CONCLUSION The process prepared Telmisartan and Amlodipine tablets is feasible.