Abstract: OBJECTIVE To provide administrations of drug safety for patients by analyzing the drug factors of adverse reaction induced by multi-drug combinations by clinical pharmacists. METHODS The drug factors which in one case of tremor may caused by multi-drug combinations in elderly patient with COPD exacerbation were analyzed by clinical pharmacist, and drug treatment were adjusted. RESULTS After physician accept and adjust the regimen, patients did not reappear tremors and other adverse drug reactions, improved discharged from hospital. CONCLUSION Clinical pharmacists with the disposal of the professional advantages of adverse drug reactions, from the perspective of pharmacy to provide scientific basis, to assist the physician for best regimen, play the synergy of the medical team, make patient access to quality health care services.