Abstract: OBJECTIVE To establish a method for determination of the contents of Pb, Cd, As, Hg, Cu in Jiebai capsule by inductively coupled plasma-mass spectrometry(ICP-MS), provide the basis for the medication safety use of Jiebai capsule. METHODS All the samples were digested by microwave, Sc 45 and In 115 of 30.0 μg·L^-1indium were used as the internal standard to determine the contents of the five elements simultaneously by ICP-MS. RESULTS The validated method indicated that correlative coefficients(r) for all elements were >0.99, and the limits of detection ranged 0.000 5-0.021 1 mg·kg^-1. The recovery rates of the method were 98.2%-105.4%, the RSD were in the range of 2.3%-3.5%. The contents of heavy metals in the 19 batches of Jiebai capsules were as follows, Pb:0.2-1.0 mg·kg^-1; Cd:0.012-0.027 mg·kg^-1; As:0.18-1.52 mg·kg^-1; Hg:0-0.151 mg·kg^-1; Cu:1.4-2.5 mg·kg^-1. Referring to foreign trade and economy green industry standards of medicinal plants and preparations and the standards of the imported Chinese medicinal herbs and Chinese patent medicine in Singapore, the results met the requirements. CONCLUSION The method is accurate, simple, sensitive and reproducible. It is suitable for the determination of the five heavy metal elements in Jiebai capsule.