新生儿常见超说明书用药的合理性探讨

Discussion on the Rationality of Common Off-label Use in Neonates

摘要: 目的分析新生儿科常见超说明书用药的合理性，为保障新生儿安全合理用药提供依据。方法收集2016年8月-2017年7月新生儿科住院患儿用药医嘱，对其中常见的超说明书用药情况进行合理性分析与评价。结果超说明书用药的存在不可避免，应根据循证医学证据强度对超说明书用药合理性进行评价。结论临床药师应参与药物超说明书用药的规范化管理，积极寻找医学证据，为临床医师提供科学合理的用药参考。

Abstract: OBJECTIVE To discuss the rationality of common off-label use in neonates, and to provide a reference for neonates safety and rational administration.METHODS Medication orders in neonatal department were collected from August 2016 to July 2017, and the rationality of common off-label use evaluated.RESULTS Off-label use was inevitably, which should be evaluated on the basis of analysis on the presence of evidence-based.CONCLUSION Clinical pharmacists shall participate in the standard management of off-label use, seek medical evidence actively, and provide scientific and reasonable suggestions to clinicians.