Abstract: OBJECTIVE To observe the effect of Qingnao tablets on meningeal micro-circulation and blood stasis model of mice.METHODS Sixty Kunming mice, SPF, male and female in half, were divided into 6 groups:Qingnao tablets (large, medium, small dose), Naoluotong capsule, the blank group and the model group. The blank and model groups were drenched normal saline of the equal volume. Then the amount of blood perfusion within 2 minutes were recorded after the mice quiet. The blood perfusion average value of 110-120 s before ligation and 230-240 s after ligation were recorded as the average perfusion value respectively. Another sixty mice, SPF, male and female half, were divided into 6 groups randomly. They were also drenched as above-mentioned method and administrated once a day for 15 d. The mice of blank group were injected with normal saline into the muscle of the back legs, while the other 5 groups were injected with an intramuscular injection of dexamethasone with a dose of 0.8 mg·kg^-1 for 15 d. The mice's eyeballs were picked to take blood and measure the whole blood viscosity within one hour after the intramuscular injection 16 days later.RESULTS Compared with the blank group, the blood flow volume of meningeal micro-circulation in model groups was decreased significantly (P<0.01). The Naoluotong and Qinnao Tablets in large dose significantly improved the reduction of the mice's brain blood flow volume caused by the legation of the bilateral carotid artery (P<0.01). The Qingnao tablets in medium dose significantly improved the reduction of the mice's brain blood flow volume caused by the legation of the bilateral carotid artery (P<0.05). The Qingnao group in large dose significantly decreased high shear and medium shear viscosity (P<0.01). The Qingnao group in medium dose significantly decreasd high shear and medium shear viscosity (P<0.05). The Qingnao group in large and medium dose significantly decreased low shear viscosity (P<0.05).CONCLUSION The Qingnao tablets can well improve the meningeal microcirculation and the blood stasis model of mice.