Abstract: OBJECTIVE To discuss the application value of the method of quality control circle(QCC) in quality management of clinical trial drugs in medical institutions by comparing the effect before and after the quality control circle activity. METHODS To analyze the main problems in clinical trial drugs management in medical institutions by using the method of QCC. It was formulated and implemented the targeted countermeasures and corrective measures, assessed the tangible and intangible results, detailed the workflow to be improved continuously. RESULTS After conducting the QCC activity, the inner error of clinical trial drugs management in medical institutions was reduced to 43 from 95. The progress rate was 54.7%, and the target rate was 104%. The ability of the crews was improved, and the management of clinical trial drugs was more standardized. CONCLUSION The QCC activity is helpful to improve the quality of the management of clinical trial drugs continuously, and to guarantee of medication safety of the subjects. It is an important method for the quality control of clinical trial drugs.