Abstract: Alzheimer's disease(AD), the most common cause of dementia, is an irreversible, progressive brain disorder. The greatest risk factor is increasing age. An impressive number of references showed that the aggregation and deposit of β-amyloid(Aβ) produced from amyloid precursor protein(APP) were the major cause of the development of AD. Although the resource and mechanisms of AD development need to be explored, there are some progresses on the modification, trafficking, sorting and degradation of APP in recently years. Here, APP modification, trafficking and processing in vitro and in vivo was summarized.