Abstract: OBJECTIVE To explore "cooperative" model for promoting the development of clinical pharmacy in primary hospital. METHODS The control of rational drug use and the model of the development of clinical pharmacy which was more practical and more generalized among the doctors was explored by investigating the research status and demands of rational drug use and combining with the current situation of clinical pharmacy in primary hospital. RESULTS & CONCLUSION The problems of drug use in primary hospitals were not less than provincial hospitals. The concept and level of rational drug use of medical personnel and the education and knowledge level of pharmacy staff were relatively low. The development of clinical pharmacy started late with low level and less staff. By the pattern of "clinical pharmacists cooperative" comprised of clinical pharmacists from several hospitals, could realize resource sharing of clinical pharmacists, mutual learning, mutual help and mutual promotion. It not only greatly improved the business level of clinical pharmacists but also changed the understanding of clinical pharmacy of the leadership. More importantly, it could improve the level of clinical rational drug use rapidly and make the clinical pharmacists and clinical pharmacy in hospital fully recognized.