Abstract: OBJECTIVE To improve the clinical understanding of Raoultella ornithinolytica. METHODS Clinical data of a case of wound infection caused by Raoultella ornithinolytica were retrospectively analyzed, and reviewed the literature. RESULTS The patient presented with pain and swelling in the upper right thigh with 10 h of limited functional activity due to an accident, the wound secretion culture after surgery showed Raoultella ornithinolytica, the patient recovered after levofloxacin therapy. CONCLUSION Raoultella ornithinolytica is becoming an emerging hospital-acquired infection, particularly after invasive procedures. The bacteria should cause clinical and infection control attention, early recognition of these isolates and proper infection control measures are necessary for controlling their spread.