Abstract: OBJECTIVE To decrease the loss rate of the preparation of hydrocortisone and chlorhexidine cetate cream, and to ensure quality of hospital preparations and improve economic efficiency by carrying out Quality Control Circle(QCC) activity.METHODS According to ten steps of QCC, the loss rate of 8 batches of hydrocortisone and chlorhexidine cetate cream in Jun 2016 to Dec 2016 were collected, the major factors of high loss rate of hydrocortisone and chlorhexidine cetate cream were analyzed, and corresponding measures were formulated and evaluated. RESULTS The loss rate of hydrocortisone and chlorhexidine cetate cream was decreased from 104.73‰ to 53.24‰ via the QCC activity, and the ability of members to solve problem, the sense of responsibility, community spirit, mental development and other intangible results had been improved. CONCLUSION The performance of QCC has obviously decreased the loss rate of hydrocortisone and chlorhexidine cetate cream. Meanwhile, the activity has increased the management level of hospital preparations.