Abstract: OBJECTIVE To observe the effect of Shugan Jianpi Huoxue(SGJPHX) decoction on brain-gut peptides in plasma of functional dyspepsia(FD) rats with liver depression and spleen deficiency. METHODS Seventy SPF female rats were randomly divided into normal group(10) and modeling group(60) according to the body weight of rats. The modeling group rats were adopted by chronic restraint stress+excess fatigue+improper diet for 21 d to form the model. After modeling, the modeling group rats were randomly divided into model group, SGJPHX high dose group, medium dose group, low dose group, Chaishao Liujunzi(CSLJZ) decoction group and domperidone group. After group division, the SGJPHX high dose group, medium dose group and low dose group rats were given SGJPHX decoction, the CSLJZ group rats were given CSLJZ decoction, the domperidone group rats were given domperidone, and the model group and normal group were given pure water for 14 d. The brain-gut peptides in plasma of FD Rats were detected by ELISA. RESULTS Compared with the model group, the content of Ghrelin, MTL in plasma of SGJPHX each dose group were significantly increased(P<0.05), and the CCK, CGRP were significantly reduced(P<0.01). The GAS in plasma of SGJPHX high dose group was significantly increased(P<0.05), the VIP in plasma of SGJPHX high dose group and medium dose group were significantly reduced(P<0.05). CONCLUSION SGJPHX decoction can regulate brain-gut peptides in plasma of FD rats with liver depression and spleen deficiency.