Abstract: OBJECTIVE To analyze the prescription of hyperthyroidism, the tendency of hyperthyroidism and the incidence of hyperthyroidism in pregnancy in Guangdong Women and Children Hospital. And to promote using drug rationally in hospital. METHODS Prescriptions for hyperthyroidism from 2013 to 2016 were analyzed. RESULTS The number of the patients with hyperthyroidism and the number of the pregnant patients with hyperthyroidism and its proportion were increased year by year form 2013 to 2016. The highest number of pregnant patients with hyperthyroidism were women aged from 30 to 39. The drugs to treat hyperthyroidism were mainly propylthiouracil, adjuvant drugs include vitamins, protection liver drugs, leukocyte elevating drugs and β-receptor antagonists. CONCLUSION The situation of medication of the patients diagnosed with hyperthyroidism are basically unchanged from 2013 to 2016, and the therapeutic drug is mainly propylthiouracil. Most pregnant women with hyperthyroidism are mainly treated with propylthiouracil + multivitamin B, and the proportion of the patient is increased year by year. The patients with hyperthyroidism combined with abnormal liver function are mainly treated with propylthiouracill + multivitamin B + propranolol + glucurolactone + coenzyme Q10. The patients with diffuse goiter combined with hyperthyroidism are mainly used in the therapeutic regimen of propyl thiouracil + multivitamin B + propranolol.