Abstract: OBJECTIVE To study the therapeutic effects of Yuyin Ruangan granule (YRG) on liver fibrosis and Yin-deficiency syndrome in rats. METHODS Replicating a model of liver fibrosis through multiple factor, and researching preventive and therapeutic effect of YRG on liver fibrosis rats by measuring indexes of hepatic fibrosis(ALT, AST, liver index, liver histopathology, hydroxyproline and collagen protein) and Yin-deficiency indexes (the quantity of eating and drinking water, locomotor activity, body weight, cAMP and cGMP). RESULTS YRG(1.08-4.32 g·kg^-1)could decrease ALT and AST in serum of liver fibrosis rats, reduce hepatic index and content of hydroxyproline and collagen protein, and remit liver fibrotic pathological changes. Meanwhile YRG could reduce water intake, put on weight, decrease frequency of activity and standing, and lower cAMP and cAMP/cGMP. CONCLUSION Rat model with hepatic fibrosis replicated by multi-factor has certain Yin-deficiency syndrome, and YRG has some preventive and therapeutic effects on liver fibrosis and its Yin-deficiency syndrome.