Abstract: OBJECTIVE To explore the effect of aloe gel on wound healing and scar formation in back of rats. METHODS Thirty-six healthy and male rats were randomly divided into blank control group, experimental group and control group, the model of dorsal wound in rats was established, after applied topically administered, the wound healing rate and the formation of hair follicles, sebaceous glands and collagen fibers in the skin tissues were evaluated. RESULTS Compared with the blank group, the appearing time of epithelium in the aloe gel group was earlier, the healing time was shorter, and the healing ratio was obviously improved (P>0.05), the contents of hair follicles, sebaceous glands and other accessory organs and type Ⅲ collagen fibers were more abundant in the skin tissues, collagen bundles were arranged more orderly. The indexes of the experimental group were close to that of the control group. CONCLUSION Aloe gel has a better therapeutic effect for skin trauma, and can inhibit the formation of scar.