Abstract: OBJECTIVE To provide a theoretical basis for the prediction of postprandial bioavailability test by in vitro dissolution test in recent years. METHODS In this paper, the effects of food, the dissolution medium and dissolution methods on the in vitro and in vivo correlation of dissolution test were reviewed. RESULTS The food effects of drug, the dissolution medium, dissolution methods and data evaluation methods had effects on the in vitro and in vivo correlations of dissolution methods and the postprandial bioavailability of oral drugs. CONCLUSION In China, there is heavy workload in consistency evaluation and few studies on postprandial bioavailability, the development of an in vitro dissolution method for predicting in vivo pharmacokinetics can reduce the research risk and cost of development.