Abstract: OBJECTIVE To evaluate the efficacy and safety of Lacidophilin Vaginal capsules combined with antifungal suppositories in sequential treatment of vulvovaginal candidiasis during pregnancy by meta-analysis. METHODS PubMed, EMbase, Cochrane libraries, CNKI, Wanfang and VIP were searched to collect pertinent references(from their inception to December, 2016). Data were extracted and evaluated by two reviewers independently with a designed extraction form. The RevMan 5.2 software was used to carry out meta analysis. RESULTS A total of 15 studies involving 2 522 patients were included. The results of meta-analysis indicated that the cure rate of Lacidophilin Vaginal capsules combined with antifungal suppositories was significantly higher than that of antifungal suppositories(P<0.000 01). The recurrence rate of Lacidophilin Vaginal capsules combined with antifungal suppositories significantly decreased than that of antifungal suppositories (P<0.000 01). There was no significant differences between the adverse drug reaction(ADR) occurrence of Lacidophilin Vaginal capsules combined with antifungal suppositories and antifungal suppositories (P=0.68). CONCLUSION Lacidophilin Vaginal capsules combined with antifungal suppositories in the treatment of vulvovaginal candidiasis during pregnancy is more effective than antifungal suppositories, with lower recurrence rate.