Abstract: OBJECTIVE To evaluate the efficacy and safety of compound glycyrrhizin combined with aciclovir in the treatment of herpes zoster. METHODS Randomized controlled trials (RCTs) of compound glycyrrhizin combined with acyclovir in the treatment of herpes zoster were retrospectively analyzed by CNKI, Wanfang Database, VIP Database and PubMed, The Cochrane Library. RESULTS A total of 23 RCTs involving 1 669 patients with herpes zoster were included. The efficacy of compound glycyrrhizin combined with aciclovir in the treatment of herpes zoster in total effective rate, pain relief time, analgesic time, crusting time, blister time, recovery time and the occurrence of postherpetic neuralgia were significantly better than single acyclovir treatment. CONCLUSION The overall efficacy of compound glycyrrhizin combined with acyclovir in the treatment of herpes zoster is superior to acyclovir alone, but results still need to be supported by more high-quality RCTs of multi-center, large sample, double-blind.