Abstract: OBJECTIVE To observe the clinical therapeutic efficacy of Xuan's Qingjie Decoction on acute purulent tonsillitis in children. METHODS Using randomized, controlled clinical research method, 60 cases that met the acute purulent tonsillitis were selected and then divided randomly into regular therapy group (which was infused the injectable Amoxycillin/Clavulanate Potassium) and combined therapy group (which was treated with Xuan's Qingjie Decoction and infused the injectable Amoxycillin/Clavulanate Potassium). After a five days' therapy course, the scale of decrease of primary symptom scores, secondary symptom scores and total scores, the main symptoms and signs improvement time, as well as the changes of laboratory indexes as criterion for effectiveness were calculated. RESULTS The primary symptom scores, secondary symptom scores and total scores in both two groups after treatment were declined markedly when compared with those before treatment (P<0.05), while the downward trend in combined therapy group was more obvious (P<0.05). The time of fever clearance, sore throat relieving, tonsil atrophying and congestion mitigating in combined therapy group were all shorter than those in regular therapy group (P<0.05). The expression level of infectious indicators such as WBC and CRP in both two groups after treatment were declined markedly when compared with those before treatment (P<0.05), while the difference of the downward trend of WBC and CRP between two groups was not statistically significant. The cure rate was 6.67%, and the total effective rate was 90.00% in regular therapy group, while the cure rate was 30.00%, and the total effective rate was 96.67% in combined therapy group. The overall curative effect in combined therapy group was superior to regular therapy group (P<0.05). CONCLUSION The use of Xuan's Qingjie Decoction on the basis of regular antibiotic therapy can improve the clinical symptoms and physical signs of children with acute purulent tonsillitis more efficiently and more quickly, and can control the infectious level significantly, thus showing a good clinical curative effect, which is worth of promotion.