Abstract: OBJECTIVE To explore the effects of different preparation process on the dissolution behavior of Glimepiride tablets. METHODS Using the dissolution and dissolution curve in pH(7.20±0.05) buffer as index, based on fluidity and compressibility to investigate the effects of power tabletting, dry granulation tabletting and wet granulation tabletting methods on the dissolution behavior of Glimepiride tablets. RESULTS It had different effects on the dissolution of Glimepiride tablets by power tabletting, dry granulation tabletting and wet granulation tabletting. CONCLUSION The Glimepiride tablets, which are made by mixing blank materials wet granulation with raw materials tabletting, has the same dissolution behavior with the reference preparation. And the production quality is stability, which is helpful for the consistency evaluation of Glimepiride tablets.