Abstract: OBJECTIVE To determine the processing technology of Crataegi Fructus charcoal in the pilot-scale study. METHODS Two UPLC methods for determination of effective components in Crataegi Fructus and its processed products were developed, one for determination of three phenolic compounds (chlorogenic acid, hyperoside and epicatechin), and the other for determination of two triterpene acids (oleanolic acid and ursolic acid). Taking the appearance characters, the total content of organic acid and the content of each of the five compounds above as the indexes, the effects of several influential factors the processing technology of Crataegi Fructus charcoal was investigated in the pilot-scale. RESULTS The best processing technology of Crataegi Fructus charcoal was as follows:processing temperature 200℃, turning frequency 40 Hz, processing time 33 min. CONCLUSION Evaluation indexes can effectively evaluate processing technology of Crataegi Fructus. The processing is stable and reliable, and can be used for the actual production.