Abstract: OBJECTIVE To study the acceptance of patients' in Internet + pharmaceutical service and the direction of future online pharmaceutical service platform, explore pharmaceutical service type and mode which patients' need. METHODS The questionnaire was self-made, formed after three rounds of expert review. The 600 questionnaires were sent to outpatient in three of Class 3A comprehensive hospital in Guangdong provience. RESULTS 417(85.5%) of the 488 patients considered it necessary for pharmacists to provide online pharmaceutical services, and the acceptance rates of online drug delivery ordering, online pharmacist consultation, online medication instructions, online pharmaceutical education, and online drugs sale were 73.5%, 78.2%, 64.3%, 70.4%, and 47.4%, respectively. Among the online pharmacist consultation channels, Wechat (68.8%) was the most popular among young and middle-aged patients, and the services including text message were preferred by older patients. The problems mainly include health insurance, operation supervision and logistics distribution, etc were existed. CONCLUSION Internet + pharmaceutical service is a new kind of service mode, worthy to be discussed. The laws and regulations should improve to guarantee the lawful rights and benefits of the patients.