Abstract: OBJECTIVE To investigate the compatibility stability of tranexamic acid injection mixed with fructose injection, invert sugar injection, fructose and sodium chloride injection. METHODS To mix with tranexamic acid injection and three kinds of solvent respectively, a variety of physical and chemical properties included the appearance of the liquid at different time (0, 1, 2, 4, 6 and 8 h) at room temperature and pH determined by pH-meter were observed. In addition, the content of tranexamic acid was determined by high performance liquid chromatography. RESULTS The three kinds of compatibility solution (the tranexamic acid injection mixed with fructose injection, invert sugar injection, fructose and sodium chloride injection) were transparent and clear liquid in 8 h. The pH value and the content of tranexamic acid didn't change basically. CONCLUSION The tranexamic acid injection can be used to mix with fructose injection, invert sugar injection, fructose and sodium chloride injection.