Abstract: Intra-abdominal adhesions are a pathological symptom characterized by abnormal connection of the peritoneum with adjacent peritoneum or celiac organs by fibrous tissue bands,which are the most common complication of abdominal surgery.However,the pathophysiology of intra-abdominal adhesions remains unknow,the effects may be a combination of multiple mechanisms.There are four pathophysiological mechanisms in general leading to the formation of intra-abdominal adhesions as follows:injury to the wall of vessels and peritoneal mesothelial cells,inflammation,lack of supplement of blood and oxygen,immune response.However,therapeutic effects and applications of present treatment such as improve the operation mode,set biofilm barrier,and drug treatment have poor effect and big limitations.Understanding the pathophysiological mechanism and analyzing the pros and cons of current research have important values on discovering new drug targets and treatment for abdominal adhesion.