Abstract: OBJECTIVE To investigate the effects of atorvastatin and coenzyme Q10 on high sensitivity C-reactive protein (hs-CRP)、endothelin 1(ET-1) and brain natriuretic peptide (BNP) levels in treatment of chronic heart failure.METHODS One hundred patients with chronic heart failure collected from January 2013 to January 2015 were digital randomly divided into two groups:50 cases of control group were treated with metoprolol tartrate+losartan+spironolactone+atorvastatin conventional drug treatment,50 cases of observation group were administration with coenzyme Q10 on the basic therapy of the control group.The heart function and hs-CRP,ET-1 and BNP levels of the two groups were compared.RESULTS The effective rate of obserration group was 94.0%,significantly higher than control group (70.0%)(P<0.05);hs-CRP,ET-1 and BNP levels of two groups was significantly decreased after treatment (P<0.05),and these levels of the observation group were much lower than those in control group after treatment (P<0.05);Fractional shortening and LVEF of two groups patients after treatment were significantly superior to those before treatment (P<0.05),while the left ventricular end diastolic diameter of the two groups were significant lower than those before treatment,the difference was significant (P<0.05);Fractional shortening and LVEF of the observation group were significantly higher than those in control group (P<0.05),while the left ventricular end diastolic diameter of the observation group were significant lower than those in control group,the difference was significant (P<0.05).The two hospitalization rate of observation group was much lower than that of control group (P<0.05).CONCLUSION Atorvastatin and coenzyme Q10 therapy in chronic heart failure patients can improve cardiovascular function and decrease the levels of hs-CRP,ET-1 and BNP,which has a exact effect.