Abstract: OBJECTIVE To study the antioxidation and anti-inflammatory effects of Antrodia camphorata polysaccharide on parkinsonian mice induced by 6-OHDA.METHODS The Parkinsonian mice were induced by 6-OHDA destruction of MFB.The mice were divided into normal group,control group,and experimental group (50,100,200 mg·kg^-1),were injected intraperitoneally.Behavioral changes were observed by swimming test and Morris water maze.RESULTS Compared with the model group,in the experimental groups,the mice GSH-Px,SOD,CAT and LDH significant increased,MDA,IL-6 and IL^-1β significant declined.The cognitive ability and action ability of mice was improved significantly.CONCLUSION The Antrodia camphorata polysaccharide can improve Parkinson's behavior,the effect may be related to the antioxidant and anti-inflammatory,which can improve the antioxidant capacity of brain tissue and reduce the expression of inflammatory cytokines.