Abstract: Astragaloside Ⅳ is a main active constituent of the Astragalus membranaceus, it has many biological activities, such as anti-neurodegenerative disease(AD, Parkinson's disease), anti-stress, anti-fibrotic, anti-virus, anti-inflammatory, etc. The anti-apoptosis effect is closely associated with many diseases. In this paper, the mechanisms of Astragaloside Ⅳ on anti-apoptosis effect related to many effects, such as death receptor pathway, mitochondrion pathway, endoplasmic reticulum pathway, PI3K/Akt pathway, MAPK pathway were reviewed, aiming at providing a reference about astragaloside Ⅳ in anti-apoptosis effect of related research for people in the future.