Abstract: OBJECTIVE To introduce pharmacy education and practice in the United States and to provide reference for hospital pharmacy development in China. METHODS Combining literature review and field study, the authors presented the institute profile, education, daily activities, pharmaceutical care practice, tele-medicine service and performance evaluation of hospital pharmacists in the University of Illinois at Chicago (UIC). RESULTS The Doctor of Pharmacy education in the United States has become increasingly mature and played an import role. The UIC pharmacy department was composed of inpatient pharmacy, outpatient pharmacy, satellite pharmacy, compounding room, clinical pharmacy, and etc. The safety and efficiency of daily activities are well guaranteed by its excellent informationization and automation. The clinical pharmaceutical service covered organ transplantation, oncology, pediatrics, anticoagulation, smoking cessation, antibiotic stewardship, chronic disease management, tele-medicine and so on. The evaluation of staff performance was embodied with rationality and humanity. CONCLUSION The high informatization and automatism of hospital pharmacy management, the systematic and refined clinical pharmaceutical care in pharmacy practice at UIC are worthy of our consideration and learning.