Abstract: OBJECTIVE To observe the clinical effect and pharmacoeconomics evaluation of indometacin enteric-coated tablets combined with danshentong capsules in the treatment of facial dermatitis. METHODS All of 118 patients were randomly divided into control group(58 cases) and test group(60 cases), control group were treated with oral administration of desloratadine citrate disodium tablets external application of tretinoin cream, and test group were treated with external oral administration of indometacin enteric-coated tablets combined with Danshentong capsules, 4 weeks of medication for both groups. RESULTS After the end of treatment, skin lesion area, EASI score and degree of itching in the test group (3.16±1.76,2.39±1.13,0.65±0.27) were lower than those in control group(6.73±2.42,5.87±1.26,1.86±0.42). The effective rate was 78.33% in test group and 56.90% in control group. The recurrence rate was 6.38% in test group, and 24.24% in control group. There was a significant difference between two groups(P<0.05). There were no serious adverse reactions found in two groups. Treatment costs respectively of test group and control group respectively were 1 873.10 yuan and 1 479.98 yuan, the C/E respectively were 23.91 and 26.01, relative to control group B, ΔC/ΔE of test group was 18.34. CONCLUSION Indometacin enteric-coated tablets combined with Danshentong capsules in the treatment of facial dermatitis have good curative effects, rapid onset and low recurrence rate, with the economic advantages worthy of clinical promotion.