Abstract: OBJECTIVE To discuss extensively drug resistant(XDR)-Acinetobacter baumannii infection treatment strategy of the nervous system. METHODS Combining with a case of XDR-Acinetobacter baumannii therapy of nervous system infection, to introduce reasonable application of polymyxin B. RESULTS According to the consensus, the clinical pharmacist recommended to use polymyxin B by local medication to strengthen the local tissue drug concentration and improve the effect of XDR-Acinetobacter baumannii treatment. At the same time, the clinical pharmacist provided the reasonable suggestions in many aspects, such as in the application of polymyxin B dosage, ways, monitoring and so on for clinician. In the end, the infection was under control without renal toxicity and nerve toxicity reaction. CONCLUSION Using polymyxin B by local medication provides a new way of thinking of XDR-Acinetobacter baumannii infections of the nervous system.