Abstract: OBJECTIVE To understand antitumor drug choice, dosage adjustment and adverse drug reaction monitoring and other related knowledge about the patients with abnormal liver function caused by illness development, the clinical pharmacists provide the basis for safe medication of the patients with such special clinical application. METHODS The clinical pharmacist implemented pharmaceutical care for one case of Ⅳ stage pancreatic cancer patient with liver metastasis and abnormal liver function. The clinical pharmacist provided medical advice about the drug choice, dosage adjustment, adverse drug reaction monitoring, combined with the patient's individual condition and related literature. RESULTS Through pharmaceutical care about the patient with two cycle of antitumor therapy, the clinical pharmacist indicated that abnormal liver function changed the pharmacokinetic characteristics of albumin-bound paclitaxel and S-1, reduced the metabolism and excretion capacity of two drugs. The clinical pharmacist suggested reducing dosage per unit area of albumin-bound paclitaxel and choosing alternate-day treatment of S-1. While the doctor didn't adjust the dosage in time, the patient appeared severe toxicity after 2 cycles of chemotherapy, such as myelosuppression(garde Ⅳ), agranulocytosis with fever, oral ulcer(grade Ⅲ). CONCLUSION Some patients with abnormal liver function can benefit from anti-tumor therapy. Doctors require full evaluation about the types of liver function injury, the etiology of bilirubin, while clinical pharmacists provide massages about metabolism characteristics and dosage adjustment of antitumor drugs. They choose anti-tumor treatment for the patients preferred low toxicity and good tolerance.