Abstract: OBJECTIVE To assess the correlation between response variability of aspirin and clopidogrel detecting by thromboelastography(TEG) and Seattle angina questionnaire(SAQ) in early stage undergoing percutaneous coronary intervention (PCI) patients.METHODS Forty-three post-PCI patients were detected maximum amplitude(MA) and inhibition rate(IR) of arachidonic acid(AA) and adenosine diphosphate(ADP) using TEG. According to AA-IR, aspirin response variability defined as: low(<50%), medium(50%-85%) and high(>85%). According to ADP-MA, clopidogrel response variability defined as: low (>47 mm), medium(31-47 mm) and high(<31 mm). The patients were divided into 3 groups by antiplatelet drug response variability: combined high response group, combined medium response group and combined low response group. SAQ assessment was performed before and 4 weeks after PCI in all patients. RESULTS Among 3 groups, the gender, age, stent count, and prevalence of hypertension and diabetes had no significant differences. SAQ scores in 3 groups had no significant differences before PCI, and increased 4 weeks after PCI. But SAQ scores in the combined low response group were lower than other groups relatively. Relevant between post-PCI SAQ scores and antiplatelet drugs response was confirmed by Pearson correlation coefficient. CONCLUSION Response variability of aspirin and clopidogrel is associated with SAQ scores in early stage post-PCI patients. Antiplatelet drug low response may be an important risk factor of angina pectoris in early stage post-PCI patients.