Abstract: OBJECTIVE To compare two different skin model of Episkin™ and Epikutis® in evaluating skin irritation and skin corrosion. METHODS According to OECD Guide Line 439 and OECD Guide Line 431, two skin tissue models were compared considering of quality control, test method, interpretation of outcome and transportation respectively. RESULTS There were differences in quality control, test method, and result judgement between two models. Both two models could meet requirement for skin irritation and corrosion test, while each had their own merits in experimental operability and cost. CONCLUSION Epikutis™ and Epikutis™ are good skin tissue models for skin irritation and skin corrosion assays in vitro.