Abstract: OBJECTIVE To discuss the rationality of intravenous omeprazole preventively used in non-ICU patients. METHODS Retrospectively collect the data from the medical record from Ningbo No.2 Hospital in February 2014 which preventively used intravenous omeprazole in non-intensive care unit and judge its rationality according to the standard. RESULTS There were 56(20.5%) reasonable cases in 273 cases of patients, while there were 217(79.5%) unreasonable cases. The unreasonable situation top three in turn were no prophylaxis indications, choice of initial drug use recommended oral dosage forms, the course was too long. CONCLUSION Currently the unreasonable situation of intravenous omeprazole preventively used is serious, the hospital management department should establish the standards, strengthen to clinical education and intervention to improve the unreasonable situation of intravenous omeprazole preventively.