甲磺酸多沙唑嗪多晶型表征研究

Characterization Study of Polymorphism of Doxazosin Mesylate

摘要: 目的研究甲磺酸多沙唑嗪晶型特征，为多晶型研究提供实验依据。方法采用X射线粉末衍射法（XRPD）、差示扫描量热法（DSC）、热重法（TG）、红外光谱分析（IR）、拉曼光谱分析及溶解性试验对甲磺酸多沙唑嗪晶A型与晶H型进行多晶型研究。结果获得甲磺酸多沙唑嗪晶A型与晶H型的表征图谱。结论 X射线粉末衍射法、差示扫描量热法与热重法可用于定性区分甲磺酸多沙唑嗪晶A型与晶H型，晶H型溶解度性质优于晶A型。

Abstract: OBJECTIVE To study the characterization of doxazosin mesylate forms and provide polymorphic research material.METHODS Characterization spectrum of form A and form H of doxazosin mesylate were detected by X-ray powder diffraction(XRPD), differential scanning calorimeter(DSC), thermo-gravimetric analysis(TG), infrared radiation(IR), Raman spectra analysis and dissolution test.RESULTS Characterization figures of form A and form H were obtained.CONCLUSION Form A and form H show difference in XRPD, DSC and TG patterns, form H has better performance in dissolution test.