Abstract: OBJECTIVE To study clinical effect of Zuojin pill combined with Deanxit in treatment of irritable bowel syndrome. METHODS A total of 80 consecutives diagnosed as irritable bowel syndrome from April 2013 to July 2014 arriving at Dongfeng Hospital, Hubei University of Medicine were individed randomly into control group and experiment group and each of 40 cases, the patients in control group received basic treatment and the patients in experiment group received Zuojin pill combined with Deanxit, then the differences of SDS, HAMA scores, traditional Chinese medicine syndrome score and clinical efficacy, complications after the follow-up were compared. RESULTS The SDS, HAMA scores in 2 groups were lower than before treatment and they in experiment group were significantly lower than control group (P<0.05). HAMA scores in 2 groups were higher than before treatment and in experiment group were significantly higher (P<0.05). The clinical total efficacy rate in experiment group were significantly higher than control group (P<0.05). CONCLUSION Zuojin pill combined with Deanxit can greatly improve clinical efficacy of patients with irritable bowel syndrome.